Molecular and cellular effects of NEDD8 activating enzyme (NAE) inhibition in myeloma

The NEDD8 activating enzyme (NAE) is upstream of the 20S proteasome in the ubiquitin/proteasome pathway and catalyzes the first step in the neddylation pathway. NEDD8 modification of cullins is required for ubiquitination of cullin-ring ligases (CRLs), which regulate degradation of a distinct subset...

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Autores principales: McMillin, Douglas W., Jacobs, Hannah M., Delmore, Jake E., Buon, Leutz, Hunter, Zachary R., Monrose, Val, Yu, Jie, Smith, Peter G., Richardson, Paul G., Anderson, Kenneth C., Treon, Steven P., Kung, Andrew L., Mitsiades, Constantine S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755358/
https://ncbi.nlm.nih.gov/pubmed/22246439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0563
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