Molecular and cellular effects of multi-targeted CDK inhibition in myeloma: Biological and clinical implications

Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumor cells in advanced vs. early stages of MM. We hypothesized that a multi-targeted CDK inhibitor with a different spectrum of activity...

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Autores principales: McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Buon, Leutz, Jacobs, Hannah M., Laubach, Jacob, Jakubikova, Jana, Ooi, Melissa, Hayden, Patrick, Schlossman, Robert, Munshi, Nikhil C., Lengauer, Christoph, Richardson, Paul G., Anderson, Kenneth C., Mitsiades, Constantine S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042406/
https://ncbi.nlm.nih.gov/pubmed/21223249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08427.x
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