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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state(1), but direct pharmacological inhibition of transcription factors has thus far proven difficult(2). However, the transcriptional machinery contains various enzymatic co-fac...

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Τόπος έκδοσης:	Nature
Κύριοι συγγραφείς:	Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B, Abraham, Brian J, Reddy, Jessica, Ficarro, Scott B, Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Christopher R, Hannett, Nancy M, McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine, Weng, Andrew P, Brown, Jennifer R, Benes, Cyril H., Marto, Jarrod A, Young, Richard A, Gray, Nathanael S.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2014
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4244910/ https://ncbi.nlm.nih.gov/pubmed/25043025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13393
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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

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