Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state(1), but direct pharmacological inhibition of transcription factors has thus far proven difficult(2). However, the transcriptional machinery contains various enzymatic co-fac...

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Publicado no:Nature
Main Authors: Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B, Abraham, Brian J, Reddy, Jessica, Ficarro, Scott B, Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Christopher R, Hannett, Nancy M, McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine, Weng, Andrew P, Brown, Jennifer R, Benes, Cyril H., Marto, Jarrod A, Young, Richard A, Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244910/
https://ncbi.nlm.nih.gov/pubmed/25043025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13393
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