Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state(1), but direct pharmacological inhibition of transcription factors has thus far proven difficult(2). However, the transcriptional machinery contains various enzymatic co-fac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B, Abraham, Brian J, Reddy, Jessica, Ficarro, Scott B, Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Christopher R, Hannett, Nancy M, McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine, Weng, Andrew P, Brown, Jennifer R, Benes, Cyril H., Marto, Jarrod A, Young, Richard A, Gray, Nathanael S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244910/
https://ncbi.nlm.nih.gov/pubmed/25043025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13393
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