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Discovery of potent and selective covalent inhibitors of JNK
The mitogen activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here we report the discovery of the first irreversible inhibitors of JNK1/2/3. We describe two JNK3 co-crystal structures at 2.60 and 2.9...
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| Huvudupphovsmän: | , , , , , , , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3270411/ https://ncbi.nlm.nih.gov/pubmed/22284361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.11.010 |
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