Discovery of potent and selective covalent inhibitors of JNK

The mitogen activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here we report the discovery of the first irreversible inhibitors of JNK1/2/3. We describe two JNK3 co-crystal structures at 2.60 and 2.9...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhang, Tinghu, Inesta-Vaquera, Francisco, Niepel, Mario, Zhang, Jianming, Ficarro, Scott B., Machleidt, Thomas, Xie, Ting, Marto, Jarrod A., Kim, NamDoo, Sim, Taebo, Laughlin, John D, Park, Hajeung, LoGrasso, Philip V., Patricelli, Matt, Nomanbhoy, Tyzoon K., Sorger, Peter K., Alessi, Dario R., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270411/
https://ncbi.nlm.nih.gov/pubmed/22284361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.11.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados