Discovery of potent and selective covalent inhibitors of JNK

The mitogen activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here we report the discovery of the first irreversible inhibitors of JNK1/2/3. We describe two JNK3 co-crystal structures at 2.60 and 2.9...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhang, Tinghu, Inesta-Vaquera, Francisco, Niepel, Mario, Zhang, Jianming, Ficarro, Scott B., Machleidt, Thomas, Xie, Ting, Marto, Jarrod A., Kim, NamDoo, Sim, Taebo, Laughlin, John D, Park, Hajeung, LoGrasso, Philip V., Patricelli, Matt, Nomanbhoy, Tyzoon K., Sorger, Peter K., Alessi, Dario R., Gray, Nathanael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270411/
https://ncbi.nlm.nih.gov/pubmed/22284361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.11.010
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker