Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity

Cyclin dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, a tool compound that specifically targets CDK14 covalently a...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Ferguson, Fleur M., Doctor, Zainab M., Ficarro, Scott B., Browne, Christopher M., Marto, Jarrod A., Johnson, Jared L., Yaron, Tomer M., Cantley, Lewis C., Kim, Nam Doo, Sim, Taebo, Berberich, Matthew J., Kalocsay, Marian, Sorger, Peter, Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588450/
https://ncbi.nlm.nih.gov/pubmed/30930164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.015
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