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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic strategy for cancers that rely on aberrant transcription; however, lack of understanding of resistance mechanisms to these agents will likely impede their clinical evolution. Here, we demonstrate upregu...
में बचाया:
| में प्रकाशित: | Cell Chem Biol |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6389506/ https://ncbi.nlm.nih.gov/pubmed/29276047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.007 |
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