Načítá se...

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Irreversible inhibition of transcriptional cyclin-dependent kinases (CDKs) provides a therapeutic strategy for cancers that rely on aberrant transcription; however, lack of understanding of resistance mechanisms to these agents will likely impede their clinical evolution. Here, we demonstrate upregu...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Chem Biol
Hlavní autoři: Gao, Yang, Zhang, Tinghu, Terai, Hideki, Ficarro, Scott B., Kwiatkowski, Nicholas, Hao, Ming-Feng, Sharma, Bandana, Christensen, Camilla L., Chipumuro, Edmond, Wong, Kwok-kin, Marto, Jarrod A., Hammerman, Peter S., Gray, Nathanael S., George, Rani E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389506/
https://ncbi.nlm.nih.gov/pubmed/29276047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.11.007
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!