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Covalent targeting of remote cysteine residues to develop CDK12 and 13 inhibitors
Cyclin-dependent kinases 12 and 13 (CDK12 and 13) play critical roles in the regulation of gene transcription. However, the absence of CDK12 and 13 inhibitors has hindered the ability to investigate the consequences of their inhibition in healthy cells and cancer cells. Here we describe the rational...
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| izdano v: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033074/ https://ncbi.nlm.nih.gov/pubmed/27571479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2166 |
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