Discovery of potent and selective covalent inhibitors of JNK

The mitogen activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellular response. Here we report the discovery of the first irreversible inhibitors of JNK1/2/3. We describe two JNK3 co-crystal structures at 2.60 and 2.9...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhang, Tinghu, Inesta-Vaquera, Francisco, Niepel, Mario, Zhang, Jianming, Ficarro, Scott B., Machleidt, Thomas, Xie, Ting, Marto, Jarrod A., Kim, NamDoo, Sim, Taebo, Laughlin, John D, Park, Hajeung, LoGrasso, Philip V., Patricelli, Matt, Nomanbhoy, Tyzoon K., Sorger, Peter K., Alessi, Dario R., Gray, Nathanael S.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270411/
https://ncbi.nlm.nih.gov/pubmed/22284361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.11.010
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