The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia

Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferation and induction of apoptosis in WM cells...

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Detalhes bibliográficos
Main Authors: Leleu, Xavier, Jia, Xiaoying, Runnels, Judith, Ngo, Hai T., Moreau, Anne-Sophie, Farag, Mena, Spencer, Joel A., Pitsillides, Costas M., Hatjiharissi, Evdoxia, Roccaro, Aldo, O'Sullivan, Garrett, McMillin, Douglas W., Moreno, Daisy, Kiziltepe, Tanyel, Carrasco, Ruben, Treon, Steven P., Hideshima, Teru, Anderson, Kenneth C., Lin, Charles P., Ghobrial, Irene M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234792/
https://ncbi.nlm.nih.gov/pubmed/17761832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-092098
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