Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - a missed opportunity

door Perez, Dominique R., Sklar, Larry A., Chigaev, Alexandre, Matlawska-Wasowska, Ksenia
Gepubliceerd in Semin Cancer Biol (2020)

Macrophage and NK-mediated Killing of Precursor-B Acute Lymphoblastic Leukemia Cells Targeted with a-Fucosylated Anti-CD19 Humanized Antibodies

door Matlawska-Wasowska, Ksenia, Ward, Elizabeth, Stevens, Samuel, Wang, Yue, Herbst, Ronald, Winter, Stuart S., Wilson, Bridget S.
Gepubliceerd in Leukemia (2013)

Characterization of the anti-CD22 targeted therapy, moxetumomab pasudotox, for B-cell precursor acute lymphoblastic leukemia

door Kinjyo, Ichiko, Matlawska-Wasowska, Ksenia, Chen, Xiaoru, Monks, Noel R., Burke, Patricia, Winter, Stuart S., Wilson, Bridget S.
Gepubliceerd in Pediatr Blood Cancer (2017)

Drugging DNA repair to target T-ALL cells

door Dasgupta, Yashodhara, Golovine, Konstantin, Nieborowska-Skorska, Margaret, Luo, Li, Matlawska-Wasowska, Ksenia, Mullighan, Charles G., Skorski, Tomasz
Gepubliceerd in Leuk Lymphoma (2017)

The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis

door Matlawska-Wasowska, Ksenia, Finn, Rebecca, Mustel, Ana, O'Byrne, Conor P, Baird, Alan W, Coffey, Eleanor T, Boyd, Aoife
Gepubliceerd in 2010

Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia

door Erasmus, M. Frank, Matlawska-Wasowska, Ksenia, Kinjyo, Ichiko, Mahajan, Avanika, Winter, Stuart S., Xu, Li, Horowitz, Michael, Lidke, Diane S., Wilson, Bridget S.
Gepubliceerd in Sci Signal (2016)

Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

door Perez, Dominique R., Smagley, Yelena, Garcia, Matthew, Carter, Mark B., Evangelisti, Annette, Matlawska-Wasowska, Ksenia, Winter, Stuart S., Sklar, Larry A., Chigaev, Alexandre
Gepubliceerd in Oncotarget (2016)

Integration of Ruxolitinib into Dose-Intensified Therapy Targeted Against a Novel JAK2 F694L Mutation in B-precursor Acute Lymphoblastic Leukemia

door Mayfield, Jodi R., Czuchlewski, David R., Gale, James M., Matlawska-Wasowska, Ksenia, Vasef, Mohammad A., Nickl, Christian, Pickett, Gavin, Ness, Scott A., Winter, Stuart S.
Gepubliceerd in Pediatr Blood Cancer (2016)

Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

door Kang, Huining, Sharma, Nitesh D., Nickl, Christian K., Devidas, Meenakshi, Loh, Mignon L., Hunger, Stephen P., Dunsmore, Kimberly P., Winter, Stuart S., Matlawska-Wasowska, Ksenia
Gepubliceerd in Biomark Res (2018)

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

door Ksionda, Olga, Mues, Marsilius, Wandler, Anica M., Donker, Lisa, Tenhagen, Milou, Jun, Jesse, Ducker, Gregory S., Matlawska-Wasowska, Ksenia, Shannon, Kevin, Shokat, Kevan M., Roose, Jeroen P.
Gepubliceerd in PLoS One (2018)

Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent

door Toma, Monika, Witusik-Perkowska, Monika, Szwed, Marzena, Stawski, Robert, Szemraj, Janusz, Drzewiecka, Malgorzata, Nieborowska-Skorska, Margaret, Radek, Maciej, Kolasa, Pawel, Matlawska-Wasowska, Ksenia, Sliwinski, Tomasz, Skorski, Tomasz
Gepubliceerd in Oncotarget (2018)

Epigenetic silencing of SOCS5 potentiates JAK‐STAT signaling and progression of T‐cell acute lymphoblastic leukemia

door Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia
Gepubliceerd in Cancer Sci (2019)

High throughput flow cytometry identifies small molecule inhibitors for drug repurposing in T-ALL

door Perez, Dominique R., Nickl, Christian K., Waller, Anna, Delgado-Martin, Cristina, Woods, Travis, Sharma, Nitesh D., Hermiston, Michelle L, Loh, Mignon L., Hunger, Stephen P., Winter, Stuart S., Chigaev, Alexandre, Edwards, Bruce, Sklar, Larry A., Matlawska-Wasowska, Ksenia
Gepubliceerd in SLAS Discov (2018)

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

door Sullivan-Reed, Katherine, Bolton-Gillespie, Elisabeth, Dasgupta, Yashodhara, Langer, Samantha, Siciliano, Micheal, Nieborowska-Skorska, Margaret, Hanamshet, Kritika, Belyaeva, Elizaveta A., Bernhardy, Andrea J., Lee, Jaewong, Moore, Morgan, Zhao, Huaqing, Valent, Peter, Matlawska-Wasowska, Ksenia, Müschen, Markus, Bhatia, Smita, Bhatia, Ravi, Johnson, Neil, Wasik, Mariusz A., Mazin, Alexander V., Skorski, Tomasz
Gepubliceerd in Cell Rep (2018)

MLL Rearrangements Impact Outcome in HOXA-deregulated T-lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

door Matlawska-Wasowska, Ksenia, Kang, Huining, Devidas, Meenakshi, Wen, Ji, Harvey, Richard C., Nickl, Christian K., Ness, Scott A., Rusch, Michael, Li, Yongjin, Onozawa, Masahiro, Martinez, Carmen, Wood, Brent L., Asselin, Barbara L., Chen, I-Ming, Roberts, Kathryn G., Baruchel, André, Soulier, Jean, Dombret, Hervé, Zhang, Jinghui, Larson, Richard S., Raetz, Elizabeth A., Carroll, William L., Winick, Naomi J., Aplan, Peter D., Loh, Mignon L., Mullighan, Charles G., Hunger, Stephen P., Heerema, Nyla A., Carroll, Andrew J., Dunsmore, Kimberly P., Winter, Stuart S.
Gepubliceerd in Leukemia (2016)

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

door Matthijssens, Filip, Sharma, Nitesh D., Nysus, Monique, Nickl, Christian K., Kang, Huining, Perez, Dominique R., Lintermans, Beatrice, Van Loocke, Wouter, Roels, Juliette, Peirs, Sofie, Demoen, Lisa, Pieters, Tim, Reunes, Lindy, Lammens, Tim, De Moerloose, Barbara, Van Nieuwerburgh, Filip, Deforce, Dieter L., Cheung, Laurence C., Kotecha, Rishi S., Risseeuw, Martijn D.P., Van Calenbergh, Serge, Takarada, Takeshi, Yoneda, Yukio, van Delft, Frederik W., Lock, Richard B., Merkley, Seth D., Chigaev, Alexandre, Sklar, Larry A., Mullighan, Charles G., Loh, Mignon L., Winter, Stuart S., Hunger, Stephen P., Goossens, Steven, Castillo, Eliseo F., Ornatowski, Wojciech, Van Vlierberghe, Pieter, Matlawska-Wasowska, Ksenia
Gepubliceerd in J Clin Invest (2021)