Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

Apoptotic evasion is a hallmark of cancer. We propose that some cancers may evade cell death by regulating 3′-5′-cyclic adenosine monophosphate (cAMP), which is associated with pro-apoptotic signaling. We hypothesize that leukemic cells possess mechanisms that efflux cAMP from the cytoplasm, thus pr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Perez, Dominique R., Smagley, Yelena, Garcia, Matthew, Carter, Mark B., Evangelisti, Annette, Matlawska-Wasowska, Ksenia, Winter, Stuart S., Sklar, Larry A., Chigaev, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085131/
https://ncbi.nlm.nih.gov/pubmed/27129155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8986
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