Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent

Cancer cells often accumulate spontaneous and treatment-induced DNA damage i.e. potentially lethal DNA double strand breaks (DSBs). Targeting DSB repair mechanisms with specific inhibitors could potentially sensitize cancer cells to the toxic effect of DSBs. Current treatment for glioblastoma includ...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Toma, Monika, Witusik-Perkowska, Monika, Szwed, Marzena, Stawski, Robert, Szemraj, Janusz, Drzewiecka, Malgorzata, Nieborowska-Skorska, Margaret, Radek, Maciej, Kolasa, Pawel, Matlawska-Wasowska, Ksenia, Sliwinski, Tomasz, Skorski, Tomasz
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305145/
https://ncbi.nlm.nih.gov/pubmed/30627327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26409
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