Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent

Cancer cells often accumulate spontaneous and treatment-induced DNA damage i.e. potentially lethal DNA double strand breaks (DSBs). Targeting DSB repair mechanisms with specific inhibitors could potentially sensitize cancer cells to the toxic effect of DSBs. Current treatment for glioblastoma includ...

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Publicado en:Oncotarget
Autores principales: Toma, Monika, Witusik-Perkowska, Monika, Szwed, Marzena, Stawski, Robert, Szemraj, Janusz, Drzewiecka, Malgorzata, Nieborowska-Skorska, Margaret, Radek, Maciej, Kolasa, Pawel, Matlawska-Wasowska, Ksenia, Sliwinski, Tomasz, Skorski, Tomasz
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305145/
https://ncbi.nlm.nih.gov/pubmed/30627327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26409
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