Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired. Perturbed Ras signaling is prevalent in T-ALL a...

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Veröffentlicht in:PLoS One
Hauptverfasser: Ksionda, Olga, Mues, Marsilius, Wandler, Anica M., Donker, Lisa, Tenhagen, Milou, Jun, Jesse, Ducker, Gregory S., Matlawska-Wasowska, Ksenia, Shannon, Kevin, Shokat, Kevan M., Roose, Jeroen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969748/
https://ncbi.nlm.nih.gov/pubmed/29799846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193849
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