High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions

Deregulated signal transduction is a cancer hallmark, and its complexity and interconnectivity imply that combination therapy should be considered, but large data volumes that cover the complexity are required in user-friendly ways. Here, we present a searchable database resource of synthetic lethal...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Mues, Marsilius, Karra, Laila, Romero-Moya, Damia, Wandler, Anica, Hangauer, Matthew J., Ksionda, Olga, Thus, Yvonne, Lindenbergh, Marthe, Shannon, Kevin, McManus, Michael T., Roose, Jeroen P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690758/
https://ncbi.nlm.nih.gov/pubmed/30970263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.045
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