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Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle

T cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive bone marrow cancer in children and adults, and chemotherapy often fails for relapsing patients. Molecularly targeted therapy is hindered by heterogeneity in T-ALL and mechanistic details of the affected pathways in T-ALL are neede...

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Библиографические подробности
Опубликовано в: :Small GTPases
Главные авторы: Mues, Marsilius, Roose, Jeroen P.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331899/
https://ncbi.nlm.nih.gov/pubmed/27159504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1187323
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