Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

Oncogenic mutations in RAS genes, like KRAS(G12D) or NRAS(G12D), trap Ras in the active state and cause myeloproliferative disorder and T cell leukemia (T-ALL) when induced in the bone marrow via Mx1CRE. The RAS exchange factor RASGRP1 is frequently overexpressed in T-ALL patients. In T-ALL cell lin...

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Publicat a:Oncogene
Autors principals: Karra, Laila, Romero-Moya, Damia, Ksionda, Olga, Krush, Milana, Gu, Zhaohui, Mues, Marsilius, Depeille, Philippe, Mullighan, Charles, Roose, Jeroen P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655557/
https://ncbi.nlm.nih.gov/pubmed/32989257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01469-8
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