Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

Oncogenic mutations in RAS genes, like KRAS(G12D) or NRAS(G12D), trap Ras in the active state and cause myeloproliferative disorder and T cell leukemia (T-ALL) when induced in the bone marrow via Mx1CRE. The RAS exchange factor RASGRP1 is frequently overexpressed in T-ALL patients. In T-ALL cell lin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Karra, Laila, Romero-Moya, Damia, Ksionda, Olga, Krush, Milana, Gu, Zhaohui, Mues, Marsilius, Depeille, Philippe, Mullighan, Charles, Roose, Jeroen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655557/
https://ncbi.nlm.nih.gov/pubmed/32989257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01469-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados