ZMP: A Master Regulator of One-Carbon Metabolism

Bằng Ducker, Gregory S., Rabinowitz, Joshua D.
Xuất bản năm Mol Cell (2015)

One-Carbon Metabolism in Health and Disease

Bằng Ducker, Gregory S., Rabinowitz, Joshua D.
Xuất bản năm Cell Metab (2016)

An LC-MS Chemical Derivatization Method for the Measurement of Five Different One-carbon States of Cellular Tetrahydrofolate

Bằng Chen, Li, Ducker, Gregory S., Lu, Wenyun, Teng, Xin, Rabinowitz, Joshua D.
Xuất bản năm Anal Bioanal Chem (2017)

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors

Bằng Okuzumi, Tatsuya, Ducker, Gregory S., Zhang, Chao, Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M.
Được phát hành 2010

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

Bằng Wang, Beatrice T., Ducker, Gregory S., Barczak, Andrea J., Barbeau, Rebecca, Erle, David J., Shokat, Kevan M.
Được phát hành 2011

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Bằng Pourdehnad, Michael, Truitt, Morgan L., Siddiqi, Imran N., Ducker, Gregory S., Shokat, Kevan M., Ruggero, Davide
Được phát hành 2013

Reversal of cytosolic one-carbon flux compensates for loss of mitochondrial folate pathway

Bằng Ducker, Gregory S., Chen, Li, Morscher, Raphael J., Ghergurovich, Jonathan M., Esposito, Mark, Teng, Xin, Kang, Yibin, Rabinowitz, Joshua D.
Xuất bản năm Cell Metab (2016)

Mitochondrial translation requires folate-dependent tRNA methylation

Bằng Morscher, Raphael J., Ducker, Gregory S., Li, Sophia Hsin-Jung, Mayer, Johannes A., Gitai, Zemer, Sperl, Wolfgang, Rabinowitz, Joshua D.
Xuất bản năm Nature (2018)

Generation of a patient-derived chordoma xenograft and characterization of the phospho-proteome in a recurrent chordoma

Bằng Davies, Jason, Robinson, Aaron E., Cowdrey, Cynthia, Mummaneni, Praveen, Ducker, Gregory S., Shokat, Kevan M., Bollen, Andrew, Hann, Byron, Phillips, Joanna J.
Xuất bản năm J Neurosurg (2013)

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination

Bằng Rodan, Lance H., Qi, Wanshu, Ducker, Gregory S., Demirbas, Didem, Laine, Regina, Yang, Edward, Walker, Melissa A., Eichler, Florian, Rabinowitz, Joshua D., Anselm, Irina, Berry, Gerard T.
Xuất bản năm Mol Genet Metab (2018)

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

Bằng Ksionda, Olga, Mues, Marsilius, Wandler, Anica M., Donker, Lisa, Tenhagen, Milou, Jun, Jesse, Ducker, Gregory S., Matlawska-Wasowska, Ksenia, Shannon, Kevin, Shokat, Kevan M., Roose, Jeroen P.
Xuất bản năm PLoS One (2018)

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

Bằng Ducker, Gregory S., Ghergurovich, Jonathan M., Mainolfi, Nello, Suri, Vipin, Jeong, Stephanie K., Hsin-Jung Li, Sophia, Friedman, Adam, Manfredi, Mark G., Gitai, Zemer, Kim, Hahn, Rabinowitz, Joshua D.
Xuất bản năm Proc Natl Acad Sci U S A (2017)

Serine metabolism supports macrophage IL-1β production.

Bằng Rodriguez, Arianne E., Ducker, Gregory S., Billingham, Leah K., Martinez, Carlos A., Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark G., Weinberg, Samuel E., Rabinowitz, Joshua D., Chandel, Navdeep S.
Xuất bản năm Cell Metab (2019)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Bằng García-Cañaveras, Juan C., Lancho, Olga, Ducker, Gregory S., Ghergurovich, Jonathan M., Xu, Xincheng, da Silva-Diz, Victoria, Minuzzo, Sonia, Indraccolo, Stefano, Kim, Hahn, Herranz, Daniel, Rabinowitz, Joshua D.
Xuất bản năm Leukemia (2020)

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

Bằng Ducker, Gregory S., Atreya, Chloe E., Simko, Jeffry P., Hom, Yun K., Matli, Mary R., Benes, Cyril H., Hann, Byron, Nakakura, Eric K., Bergsland, Emily K., Donner, David B., Settleman, Jeffrey, Shokat, Kevan M., Warren, Robert S.
Được phát hành 2013

Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

Bằng Li, Albert M., Ducker, Gregory S., Li, Yang, Seoane, Jose A., Xiao, Yiren, Melemenidis, Stavros, Zhou, Yiren, Liu, Ling, Vanharanta, Sakari, Graves, Edward E., Rankin, Erinn B., Curtis, Christina, Massagué, Joan, Rabinowitz, Joshua D., Thompson, Craig B., Ye, Jiangbin
Xuất bản năm Mol Cancer Res (2020)

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

Bằng Panic, Vanja, Pearson, Stephanie, Banks, James, Tippetts, Trevor S, Velasco-Silva, Jesse N, Lee, Sanghoon, Simcox, Judith, Geoghegan, Gisela, Bensard, Claire L, van Ry, Tyler, Holland, Will L, Summers, Scott A, Cox, James, Ducker, Gregory S, Rutter, Jared, Villanueva, Claudio J
Xuất bản năm eLife (2020)

A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors

Bằng Chamberlain, Chester E., German, Michael S., Yang, Katherine, Wang, Jason, VanBrocklin, Henry, Regan, Melanie, Shokat, Kevan M., Ducker, Gregory S., Kim, Grace E., Hann, Byron, Donner, David B., Warren, Robert S., Venook, Alan P., Bergsland, Emily K., Lee, Danny, Wang, Yucheng, Nakakura, Eric K.
Xuất bản năm Mol Cancer Ther (2018)

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy

Bằng Dekhne, Aamod S., Shah, Khushbu, Ducker, Gregory S., Katinas, Jade M., Wong-Roushar, Jennifer, Nayeen, Junayed, Doshi, Arpit, Ning, Changwen, Bao, Xun, Frühauf, Josephine, Liu, Jenney, Wallace-Povirk, Adrianne, O’Connor, Carrie, Dzinic, Sijana H., White, Kathryn, Kushner, Juiwanna, Kim, Seongho, Hüttemann, Maik, Polin, Lisa, Rabinowitz, Joshua D., Li, Jing, Hou, Zhanjun, Dann, Charles E., Gangjee, Aleem, Matherly, Larry H.
Xuất bản năm Mol Cancer Ther (2019)

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Bằng Bensard, Claire L., Wisidagama, Dona R., Olson, Kristofor A., Berg, Jordan A., Krah, Nathan M., Schell, John C., Nowinski, Sara M., Fogarty, Sarah, Bott, Alex J., Wei, Peng, Dove, Katja K., Tanner, Jason M., Panic, Vanja, Cluntun, Ahmad, Lettlova, Sandra, Earl, Christian S., Namnath, David F., Vázquez-Arregun, Karina, Villanueva, Claudio J., Tantin, Dean, Murtaugh, L. Charles, Evason, Kimberley J., Ducker, Gregory S., Thummel, Carl S., Rutter, Jared
Xuất bản năm Cell Metab (2019)