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Synthesis and evaluation of indazole based analog sensitive Akt inhibitors
The kinase Akt is a key signaling node in regulating cellular growth and survival. It is implicated in cancer by mutation and its role in the downstream transmission of aberrant PI3K signaling. For these reasons, Akt has become an increasingly important target of drug development efforts and several...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932704/ https://ncbi.nlm.nih.gov/pubmed/20582381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c003917a |
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