Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial isozyme...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ducker, Gregory S., Ghergurovich, Jonathan M., Mainolfi, Nello, Suri, Vipin, Jeong, Stephanie K., Hsin-Jung Li, Sophia, Friedman, Adam, Manfredi, Mark G., Gitai, Zemer, Kim, Hahn, Rabinowitz, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664509/
https://ncbi.nlm.nih.gov/pubmed/29073064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706617114
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