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Mitochondrial translation requires folate-dependent tRNA methylation
Folates enable the activation and transfer of one-carbon units for biosynthesis of purines, thymidine and methionine(1–3). Antifolates are important immunosuppressive(4) and anticancer agents(5). In proliferating lymphocytes(6) and human cancers(7,8), folate enzymes localizing to the mitochondria ar...
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| Gepubliceerd in: | Nature |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6020024/ https://ncbi.nlm.nih.gov/pubmed/29364879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25460 |
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