Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2, 3-d]pyrimidin-2-amines as microtubule inhibitors

Por Gangjee, Aleem, Kurup, Sonali, Smith, Charles D.
Publicado em 2013

Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo-[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents()

Por Gangjee, Aleem, Yang, Jie, Queener, Sherry F.
Publicado em 2006

The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

Por Matherly, Larry H., Hou, Zhanjun, Gangjee, Aleem
Publicado no Cancer Chemother Pharmacol (2017)

The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

Por Cody, Vivian, Pace, Jim, Lin, Lu, Gangjee, Aleem
Publicado em 2009

Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates

Por Gangjee, Aleem, Qiu, Yibin, Li, Wei, Kisliuk, Roy L.
Publicado em 2008

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofol...

Por Gangjee, Aleem, Li, Wei, Yang, Jie, Kisliuk, Roy L.
Publicado em 2007

Structure–activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

Por Cody, Vivian, Pace, Jim, Namjoshi, Ojas A., Gangjee, Aleem
Publicado no Acta Crystallogr F Struct Biol Commun (2015)

CoMFA Analysis of tgDHFR and rlDHFR Based on Antifolates with 6-5 Fused Ring System Using the All-Orientation Search (AOS) Routine and a Modified Cross-Validated r(2)-Guided Region...

Por Gangjee, Aleem, Lin, Xin, Biondo, Lisa R., Queener, Sherry F.
Publicado em 2010

The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines

Por Gangjee, Aleem, Namjoshi, Ojas A., Ihnat, Michael A., Buchanan, Aaron
Publicado em 2010

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-­diaminofuro[2,3-d]pyrimidi...

Por Cody, Vivian, Piraino, Jennifer, Pace, Jim, Li, Wei, Gangjee, Aleem
Publicado em 2010

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

Por Desmoulin, Sita Kugel, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Publicado em 2012

Discovery of Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance(1)

Por Gangjee, Aleem, Yu, Jianming, Copper, Jean E., Smith, Charles D.
Publicado em 2007

N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase

Por Gangjee, Aleem, Adair, Ona O., Pagley, Michelle, Queener, Sherry F.
Publicado em 2008

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates1

Por Gangjee, Aleem, Zeng, Yibin, McGuire, John J., Kisliuk, Roy L.
Publicado em 2005

2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance(1)

Por Gangjee, Aleem, Namjoshi, Ojas A., Keller, Staci N., Smith, Charles D.
Publicado em 2011

Synthesis and Biological Activities of (R)- and (S)-N-(4-methoxy-phenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride as Potent Cytotoxic Antitubulin Ag...

Por Gangjee, Aleem, Zhao, Ying, Hamel, Ernest, Westbrook, Cara, Mooberry, Susan L.
Publicado em 2011

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates

Por Gangjee, Aleem, Yang, Jie, McGuire, John J., Kisliuk, Roy L.
Publicado em 2006

The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase...

Por Gangjee, Aleem, Jain, Hiteshkumar D., Queener, Sherry F., Kisliuk, Roy L.
Publicado em 2008

Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Por Zaware, Nilesh, Kisliuk, Roy, Bastian, Anja, Ihnat, Michael A., Gangjee, Aleem
Publicado no Bioorg Med Chem Lett (2017)

Synthesis and Biological Activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as Vascular Endothelial Growth Factor Receptor-2...

Por Gangjee, Aleem, Kurup, Sonali, Ihnat, Michael A, Thorpe, Jessica E., Shenoy, Satyendra S.
Publicado em 2010