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Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

In an effort to optimize the structural requirements for combined cytostatic and cytotoxic effects in single agents, a series of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines 3-7 were synthesized and evaluated as inhibitors of receptor tyrosine kinases (RTKs) as well as thymidylate synthase (TS...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Zaware, Nilesh, Kisliuk, Roy, Bastian, Anja, Ihnat, Michael A., Gangjee, Aleem
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398096/
https://ncbi.nlm.nih.gov/pubmed/28258797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.02.018
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