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Janus Compounds, 5-Chloro-N(4)-methyl-N(4)-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations show...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Rohena, Cristina C., Risinger, April L., Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F., Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470396/
https://ncbi.nlm.nih.gov/pubmed/27918450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21121661
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