Structure based drug design and in vitro metabolism study: discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent

Por Xiang, Weiguo, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Publicado no Bioorg Med Chem (2018)

Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angio...

Por Pavana, Roheeth Kumar, Choudhary, Shruti, Bastian, Anja, Ihnat, Michael A., Bai, Raouli, Hamel, Ernest, Gangjee, Aleem
Publicado no Bioorg Med Chem (2016)

Optimization of the linker domain in a dimeric compound that degrades an r(CUG) repeat expansion in cells

Por Benhamou, Raphael I., Abe, Masahito, Choudhary, Shruti, Meyer, Samantha M., Angelbello, Alicia J., Disney, Matthew D.
Publicado no J Med Chem (2020)

Potential of Substituted Quinazolines to Interact with Multiple Targets in the Treatment of Cancer

Por Choudhary, Shruti, Doshi, Arpit, Luckett-Chastain, Lerin, Ihnat, Michael, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Publicado no Bioorg Med Chem (2021)

Design, Synthesis, and Structure–Activity Relationships of Pyrimido[4,5-b]indole-4-amines as Microtubule Depolymerizing Agents that are Effective against Multidrug Resistant Cells...

Por Devambatla, Ravi Kumar Vyas, Li, Wei, Zaware, Nilesh, Choudhary, Shruti, Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Publicado no Bioorg Med Chem Lett (2017)

Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

Por Benhamou, Raphael I, Vezina-Dawod, Simon, Choudhary, Shruti, Wang, Kye Won, Meyer, Samantha M, Yildirim, Ilyas, Disney, Matthew D
Publicado no Chembiochem (2020)

Catalytic Isonitrile Insertions and Condensations Initiated by RNC–X Complexation

Por Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.
Publicado no Adv Synth Catal (2014)

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer...

Por Devambatla, Ravi Kumar Vyas, Namjoshi, Ojas A., Choudhary, Shruti, Hamel, Ernest, Shaffer, Corena V., Rohena, Cristina C., Mooberry, Susan L., Gangjee, Aleem
Publicado no J Med Chem (2016)

Janus Compounds, 5-Chloro-N(4)-methyl-N(4)-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Por Rohena, Cristina C., Risinger, April L., Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F., Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L.
Publicado no Molecules (2016)

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

Por Ursu, Andrei, Wang, Kye Won, Bush, Jessica A, Choudhary, Shruti, Chen, Jonathan L, Baisden, Jared T, Zhang, Yong-Jie, Gendron, Tania F, Petrucelli, Leonard, Yildirim, Ilyas, Disney, Matthew D
Publicado no ACS Chem Biol (2020)

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

Por Angelbello, Alicia J., Benhamou, Raphael I., Rzuczek, Suzanne G., Choudhary, Shruti, Tang, Zhenzhi, Chen, Jonathan L., Roy, Madhuparna, Wang, Kye Won, Yildirim, Ilyas, Jun, Albert S., Thornton, Charles A., Disney, Matthew D.
Publicado no Cell Chem Biol (2020)