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Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angiokinase Inhibition as Antitumor Agents

The utility of cytostatic antiangiogenic agents (AA) in cancer chemotherapy lies in their combination with cytotoxic chemotherapeutic agents. Clinical combinations of AA with microtubule targeting agents (MTAs) have been particularly successful. The discovery, synthesis and biological evaluations of...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem
Autors principals: Pavana, Roheeth Kumar, Choudhary, Shruti, Bastian, Anja, Ihnat, Michael A., Bai, Raouli, Hamel, Ernest, Gangjee, Aleem
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5191990/
https://ncbi.nlm.nih.gov/pubmed/27894589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.11.026
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