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Novel Water Soluble, Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis and Biological Evaluation as Antitubulin Antitumor Agents
PURPOSE: To study the effects of a regioisomeric change on the biological activities of previously reported water soluble, colchicine site binding, microtubule depolymerizing agents. METHODS: Nine pyrrolo[3,2-d]pyrimidines were designed and synthesized. The importance of various substituents was eva...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3474888/ https://ncbi.nlm.nih.gov/pubmed/22814902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0816-3 |
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