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The Design, Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multi-targeted Receptor Tyrosine Kinase and Microtubule Inhibitors as Potential Antitumor Agents

A series of eleven conformationally restricted, 4-substituted 2,6-dimethylfuro[2,3-d]pyrimidines was designed to explore the bioactive conformation required for dual inhibition of microtubule assembly and receptor tyrosine kinases (RTKs), and their biological activities are reported. All three rotat...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Zhang, Xin, Raghavan, Sudhir, Ihnat, Michael, Hamel, Ernest, Zammiello, Cynthia, Bastian, Anja, Mooberry, Susan L., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410085/
https://ncbi.nlm.nih.gov/pubmed/25882519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.061
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