A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells

Por Longeras, Richard, Farjo, Krysten, Ihnat, Michael, Ma, Jian-Xing
Publicado em 2012

The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines

Por Gangjee, Aleem, Namjoshi, Ojas A., Ihnat, Michael A., Buchanan, Aaron
Publicado em 2010

Targeting dormant micrometastases: rationale, evidence to date and clinical implications

Por Hurst, Robert E., Bastian, Anja, Bailey-Downs, Lora, Ihnat, Michael A.
Publicado no Ther Adv Med Oncol (2016)

Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Por Zaware, Nilesh, Kisliuk, Roy, Bastian, Anja, Ihnat, Michael A., Gangjee, Aleem
Publicado no Bioorg Med Chem Lett (2017)

FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis

Por Eckert, Jeffrey, Scott, Brian, Lawrence, Shelley M, Ihnat, Michael, Chaaban, Hala
Publicado no J Inflamm Res (2017)

Synthesis and Biological Activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as Vascular Endothelial Growth Factor Receptor-2...

Por Gangjee, Aleem, Kurup, Sonali, Ihnat, Michael A, Thorpe, Jessica E., Shenoy, Satyendra S.
Publicado em 2010

Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7 H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents1

Por Gangjee, Aleem, Zhao, Ying, Raghavan, Sudhir, Ihnat, Michael A., Disch, Bryan C.
Publicado em 2010

N(4)-aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors

Por Gangjee, Aleem, Kurup, Sonali, Ihnat, Michael A, Thorpe, Jessica E., Disch, Bryan
Publicado em 2011

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor...

Por Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Ihnat, Michael, Shenoy, Satyendra, Kisliuk, Roy L.
Publicado em 2010

N(4)-(3-bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as Potent Multiple Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and In vivo Evaluation

Por Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Yang, Jie, Thorpe, Jessica E., Ihnat, Michael A.
Publicado em 2012

SOCS3 Modulates Interleukin-6R Signaling Preference in Dermal Fibroblasts

Por Luckett-Chastain, Lerin R., Ihnat, Michael A., Mickle-Kawar, Bethany M., Gallucci, Randle Michael
Publicado em 2012

Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents

Por Gangjee, Aleem, Namjoshi, Ojas A., Yu, Jianming, Ihnat, Michael A., Thorpe, Jessica E., Warnke, Linda A.
Publicado em 2008

Synthesis and Evaluation of Novel Tc-99m Labeled Probestin Conjugates for Imaging APN/CD13 Expression In Vivo

Por Pathuri, Gopal, Hedrick, Andria F., Disch, Bryan, Doan, John, Ihnat, Michael A., Awasthi, Vibhudutta, Gali, Hariprasad
Publicado em 2011

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

Por Towner, Rheal A., Ihnat, Michael, Saunders, Debra, Bastian, Anja, Smith, Nataliya, Pavana, Roheeth Kumar, Gangjee, Aleem
Publicado no BMC Cancer (2015)

Discovery and Preclinical Evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as Single Agents with Microtubule Targeting Effects along with Triple-acting Angio...

Por Pavana, Roheeth Kumar, Choudhary, Shruti, Bastian, Anja, Ihnat, Michael A., Bai, Raouli, Hamel, Ernest, Gangjee, Aleem
Publicado no Bioorg Med Chem (2016)

Interleukin (IL)-6 modulates transforming growth factor -β receptor I and II (TGF-βRI and II) function in epidermal keratinocytes

Por Luckett-Chastain, Lerin R., Cottrell, Mackenzie L., Kawar, Bethany M., Ihnat, Michael A., Gallucci, Randle M.
Publicado no Exp Dermatol (2017)

Novel tricyclic indeno[2, 1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

Por Gangjee, Aleem, Zhao, Ying, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C., Kisliuk, Roy L.
Publicado em 2012

N(2)-Trimethylacetyl substituted and unsubstituted-N(4)-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinas...

Por Gangjee, Aleem, Namjoshi, Ojas A., Yu, Jianming, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C.
Publicado em 2013

Synthesis and biological activity of 5-chloro-N(4)-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangi...

Por Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Disch, Bryan C., Thorpe, Jessica E., Bastian, Anja, Ihnat, Michael A
Publicado em 2013

The Design, Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multi-targeted Receptor Tyrosine Kinase and Micro...

Por Zhang, Xin, Raghavan, Sudhir, Ihnat, Michael, Hamel, Ernest, Zammiello, Cynthia, Bastian, Anja, Mooberry, Susan L., Gangjee, Aleem
Publicado no Bioorg Med Chem (2015)