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N(4)-aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors

Six novel N(4)-substitutedphenyl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines were synthesized as multiple receptor tyrosine kinase (RTK) inhibitors and antitumor agents. An improvement in the inhibitory potency against epidermal growth factor receptor (EGFR), vascular endothel...

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Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Kurup, Sonali, Ihnat, Michael A, Thorpe, Jessica E., Disch, Bryan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276368/
https://ncbi.nlm.nih.gov/pubmed/22204741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.11.058
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