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Synthesis and Biological Activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as Vascular Endothelial Growth Factor Receptor-2 Inhibitors and Antiangiogenic and Antitumor Agents

A series of eight N(4)-phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines 8–15 were synthesized as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with varied substitutions in the phenyl ring of the 4-anilino moiety. In addition, five N(4)-phen...

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Bibliographische Detailangaben
Hauptverfasser: Gangjee, Aleem, Kurup, Sonali, Ihnat, Michael A, Thorpe, Jessica E., Shenoy, Satyendra S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868963/
https://ncbi.nlm.nih.gov/pubmed/20403700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.03.052
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