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N(4)-(3-bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as Potent Multiple Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and In vivo Evaluation

With the goal of developing multitargeted receptor tyrosine kinase inhibitors that display potent inhibition against PDGFRβ and VEGFR-2 we designed and synthesized eleven N(4)-(3-bromophenyl)-7-(substitutedbenzyl) pyrrolo[2,3-d]pyrimidines 9a–19a. These compounds were obtained from the key intermedi...

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Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Yang, Jie, Thorpe, Jessica E., Ihnat, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310894/
https://ncbi.nlm.nih.gov/pubmed/22370340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.01.029
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