Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7 H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents1

Por Gangjee, Aleem, Zhao, Ying, Raghavan, Sudhir, Ihnat, Michael A., Disch, Bryan C.
Publicado em 2010

Synthesis and biological activity of 5-chloro-N(4)-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangi...

Por Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Disch, Bryan C., Thorpe, Jessica E., Bastian, Anja, Ihnat, Michael A
Publicado em 2013

Discovery of Antitubulin Agents with Antiangiogenic Activity as Single Entities with Multitarget Chemotherapy Potential

Por Gangjee, Aleem, Pavana, Roheeth Kumar, Ihnat, Michael A., Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Bailey-Downs, Lora C., Hamel, Ernest, Bai, Rouli
Publicado em 2014

Development and Characterization of a Preclinical Model of Breast Cancer Lung Micrometastatic to Macrometastatic Progression

Por Bailey-Downs, Lora C., Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Hauser, Paul J., Farasyn, Taleah, Berry, William L., Hurst, Robert E., Ihnat, Michael A.
Publicado em 2014

A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

Por Bastian, Anja, Thorpe, Jessica E., Disch, Bryan C., Bailey-Downs, Lora C., Gangjee, Aleem, Devambatla, Ravi K. V., Henthorn, Jim, Humphries, Kenneth M., Vadvalkar, Shraddha S., Ihnat, Michael A.
Publicado no J Pharmacol Exp Ther (2015)

The Design and Discovery of Water Soluble 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multitargeted Receptor Tyrosine Kinase Inhibitors and Microtubule Targeting Antitumor...

Por Zhang, Xin, Raghavan, Sudhir, Ihnat, Michael, Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Bailey-Downs, Lora C., Dybdal-Hargreaves, Nicholas F., Rohena, Cristina C., Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Publicado em 2014