Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates

Por Gangjee, Aleem, Qiu, Yibin, Li, Wei, Kisliuk, Roy L.
Publicado em 2008

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofol...

Por Gangjee, Aleem, Li, Wei, Yang, Jie, Kisliuk, Roy L.
Publicado em 2007

Folate Replacement by Tetrahydrohomopteroate in Triazine-Resistant Bacteria

Por Genther, Clara S., Roszmann, John H., Smith, Carl C., Kisliuk, Roy L.
Publicado em 1971

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates1

Por Gangjee, Aleem, Zeng, Yibin, McGuire, John J., Kisliuk, Roy L.
Publicado em 2005

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates

Por Gangjee, Aleem, Yang, Jie, McGuire, John J., Kisliuk, Roy L.
Publicado em 2006

The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase...

Por Gangjee, Aleem, Jain, Hiteshkumar D., Queener, Sherry F., Kisliuk, Roy L.
Publicado em 2008

Synthesis and Evaluation of 5-(Arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Por Zaware, Nilesh, Kisliuk, Roy, Bastian, Anja, Ihnat, Michael A., Gangjee, Aleem
Publicado no Bioorg Med Chem Lett (2017)

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor...

Por Gangjee, Aleem, Zaware, Nilesh, Raghavan, Sudhir, Ihnat, Michael, Shenoy, Satyendra, Kisliuk, Roy L.
Publicado em 2010

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrof...

Por Zhang, Xin, Zhou, Xilin, L.Kisliuk, Roy, Piraino, Jennifer, Cody, Vivian, Gangjee, Aleem
Publicado em 2011

Conformational Changes Induced in Dihydrofolate Reductase by Folates, Pyridine Nucleotide Coenzymes, and Methotrexate

Por Pastore, Edward J., Kisliuk, Roy L., Plante, Laurence T., Wright, John M., Kaplan, Nathan O.
Publicado em 1974

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethyl-thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofo...

Por Gangjee, Aleem, Li, Wei, Kisliuk, Roy L., Cody, Vivian, Pace, Jim, Piriano, Jennifer, Makin, Jennifer
Publicado em 2009

2,4-Diamino-5-methyl-6-substituted Arylthio-furo[2,3-d]pyrimidines as Novel Classical and Nonclassical Antifolates as Potential Dual Thymidylate Synthase and Dihydrofolate Reductas...

Por Gangjee, Aleem, Jain, Hiteshkumar D., Phan, Jaclyn, Guo, Xin, Queener, Sherry F., Kisliuk, Roy L.
Publicado em 2009

Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles

Por Gangjee, Aleem, Namjoshi, Ojas A., Raghavan, Sudhir, Queener, Sherry F., Kisliuk, Roy L., Cody, Vivian
Publicado em 2013

Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates

Por Gangjee, Aleem, Zeng, Yibin, Talreja, Tina, McGuire, John J., Kisliuk, Roy L., Queener, Sherry F.
Publicado em 2007

Novel tricyclic indeno[2, 1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

Por Gangjee, Aleem, Zhao, Ying, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C., Kisliuk, Roy L.
Publicado em 2012

Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumour Agents: Design, Synthesis and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]py...

Por Gangjee, Aleem, Jain, Hiteshkumar D., Phan, Jaclyn, Lin, Xin, Song, Xiaohong, McGuire, John J., Kisliuk, Roy L.
Publicado em 2006