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Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates

The classical antifolate N-{4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3–17) were synthesized as potential dihydrofolate reductase (DHFR) inhibitors and as antitumor agents. 5-Ethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diam...

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Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Zeng, Yibin, Talreja, Tina, McGuire, John J., Kisliuk, Roy L., Queener, Sherry F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850752/
https://ncbi.nlm.nih.gov/pubmed/17552508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070165j
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