A carregar...

The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents(1a-e)

Novel classical antifolates (3 and 4) and 17 nonclassical antifolates (11-27) were synthesized as antitumor and/or antiopportunistic infection agents. Intermediates for the synthesis of 3, 4, and 11-27 were 2,4-diamino-5-alkylsubstituted-7H-pyrrolo[2,3-d]pyrimidines, 31 and 38, prepared by a ring tr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Jain, Hiteshkumar D., Queener, Sherry F., Kisliuk, Roy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858179/
https://ncbi.nlm.nih.gov/pubmed/18605720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800244v
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!