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The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents(1a-e)

Novel classical antifolates (3 and 4) and 17 nonclassical antifolates (11-27) were synthesized as antitumor and/or antiopportunistic infection agents. Intermediates for the synthesis of 3, 4, and 11-27 were 2,4-diamino-5-alkylsubstituted-7H-pyrrolo[2,3-d]pyrimidines, 31 and 38, prepared by a ring tr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gangjee, Aleem, Jain, Hiteshkumar D., Queener, Sherry F., Kisliuk, Roy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858179/
https://ncbi.nlm.nih.gov/pubmed/18605720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800244v
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