Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence

av Disney, Matthew D., Angelbello, Alicia J.
I publikationen Acc Chem Res (2016)

Bleomycin Can Cleave an Oncogenic Noncoding RNA

av Angelbello, Alicia J., Disney, Matthew D.
I publikationen Chembiochem (2017)

A Toxic RNA Templates the Synthesis of its own Fluorogenic Inhibitor by Using a Bioorthogonal Tetrazine Ligation in Cells and Tissues

av Angelbello, Alicia J., Disney, Matthew D.
I publikationen ACS Chem Biol (2020)

Small molecule targeting of RNA structures in neurological disorders

av Angelbello, Alicia J., Chen, Jonathan L., Disney, Matthew D.
I publikationen Ann N Y Acad Sci (2019)

A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways

av Benhamou, Raphael I., Angelbello, Alicia J., Wang, Eric T., Disney, Matthew D.
I publikationen Cell Chem Biol (2020)

Development of Pharmacophore Models for Small Molecules Targeting RNA: Application to the RNA Repeat Expansion in Myotonic Dystrophy Type 1

av Angelbello, Alicia J., González, Àlex L., Rzuczek, Suzanne G., Disney, Matthew D.
I publikationen Bioorg Med Chem Lett (2016)

Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate

av Angelbello, Alicia J., DeFeo, Mary E., Glinkerman, Christopher M., Boger, Dale L., Disney, Matthew D.
I publikationen ACS Chem Biol (2020)

Optimization of the linker domain in a dimeric compound that degrades an r(CUG) repeat expansion in cells

av Benhamou, Raphael I., Abe, Masahito, Choudhary, Shruti, Meyer, Samantha M., Angelbello, Alicia J., Disney, Matthew D.
I publikationen J Med Chem (2020)

Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion

av Vezina-Dawod, Simon, Angelbello, Alicia J., Choudhary, Shruti, Wang, Kye Won, Yildirim, Ilyas, Disney, Matthew D.
I publikationen ACS Med Chem Lett (2021)

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

av Benhamou, Raphael I., Angelbello, Alicia J., Andrews, Ryan J., Wang, Eric T., Moss, Walter N., Disney, Matthew D.
I publikationen ACS Chem Biol (2020)

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes

av Angelbello, Alicia J., Chen, Jonathan L., Childs-Disney, Jessica L., Zhang, Peiyuan, Wang, Zi-Fu, Disney, Matthew D.
I publikationen Chem Rev (2018)

Gini coefficients as a single value metric to define chemical probe selectivity

av Ursu, Andrei, Childs-Disney, Jessica L., Angelbello, Alicia J., Costales, Matthew G., Meyer, Samantha M., Disney, Matthew D.
I publikationen ACS Chem Biol (2020)

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

av Angelbello, Alicia J., Rzuczek, Suzanne G., Mckee, Kendra K., Chen, Jonathan L., Olafson, Hailey, Cameron, Michael D., Moss, Walter N., Wang, Eric T., Disney, Matthew D.
I publikationen Proc Natl Acad Sci U S A (2019)

Design of small molecules targeting RNA structure from sequence

av Ursu, Andrei, Childs-Disney, Jessica L., Andrews, Ryan J., O’Leary, Collin A., Meyer, Samantha M., Angelbello, Alicia J., Moss, Walter N., Disney, Matthew D.
I publikationen Chem Soc Rev (2020)

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

av Angelbello, Alicia J., Benhamou, Raphael I., Rzuczek, Suzanne G., Choudhary, Shruti, Tang, Zhenzhi, Chen, Jonathan L., Roy, Madhuparna, Wang, Kye Won, Yildirim, Ilyas, Jun, Albert S., Thornton, Charles A., Disney, Matthew D.
I publikationen Cell Chem Biol (2020)

Approved Anti-Cancer Drugs Target Oncogenic Non-Coding RNAs

av Velagapudi, Sai Pradeep, Costales, Matthew G., Vummidi, Balayeshwanth R., Nakai, Yoshio, Angelbello, Alicia J., Tran, Tuan, Haniff, Hafeez S., Matsumoto, Yasumasa, Wang, Zi Fu, Chatterjee, Arnab K., Childs-Disney, Jessica L., Disney, Matthew D.
I publikationen Cell Chem Biol (2018)