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Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion
[Image: see text] RNA contributes to disease pathobiology and is an important therapeutic target. The downstream biology of disease-causing RNAs can be short-circuited with small molecules that recognize structured regions. The discovery and optimization of small molecules interacting with RNA is, h...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2021
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8201483/ https://ncbi.nlm.nih.gov/pubmed/34141068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00027 |
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