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A Toxic RNA Templates the Synthesis of its own Fluorogenic Inhibitor by Using a Bioorthogonal Tetrazine Ligation in Cells and Tissues
Expanded RNA repeats cause >30 incurable diseases. One approach to mitigate their toxicity is by using small molecules that assemble into potent, oligomeric species upon binding to the disease-causing RNA in cells. Herein, we show that the expanded repeat [r(CUG)(exp)] that causes myotonic dystro...
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| Publicado en: | ACS Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7392402/ https://ncbi.nlm.nih.gov/pubmed/32551539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00417 |
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