Lataa...
Synthesis of N(4)-(Substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and Identification of New Microtubule Disrupting Compounds that are Effective against Multidrug Resistant Cells1
A series of fourteen N(4)-(substituted phenyl)-N(4)-methyl/desmethyl-9H-pyrimido[4,5-b]indole-2,4-diamines was synthesized as potential microtubule targeting agents. The synthesis involved a Fisher indole cyclization of 2-amino-6-hydrazinylpyrimidin-4(3H)-one with cyclohexanone, followed by oxidatio...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572549/ https://ncbi.nlm.nih.gov/pubmed/23332369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.010 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|