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Synthesis of N(4)-(Substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and Identification of New Microtubule Disrupting Compounds that are Effective against Multidrug Resistant Cells1

A series of fourteen N(4)-(substituted phenyl)-N(4)-methyl/desmethyl-9H-pyrimido[4,5-b]indole-2,4-diamines was synthesized as potential microtubule targeting agents. The synthesis involved a Fisher indole cyclization of 2-amino-6-hydrazinylpyrimidin-4(3H)-one with cyclohexanone, followed by oxidatio...

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Dettagli Bibliografici
Autori principali: Gangjee, Aleem, Zaware, Nilesh, Devambatla, Ravi Kumar Vyas, Raghavan, Sudhir, Westbrook, Cara D., Dybdal-Hargreaves, Nicholas F., Hamel, Ernest, Mooberry, Susan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572549/
https://ncbi.nlm.nih.gov/pubmed/23332369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.010
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