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The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

This review considers the “promise” of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in 2006 and was identified as the principal folate transporter involved in the intestinal absorption of dietary folates. The recognition t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Chemother Pharmacol
Hauptverfasser: Matherly, Larry H., Hou, Zhanjun, Gangjee, Aleem
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756103/
https://ncbi.nlm.nih.gov/pubmed/29127457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3473-8
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