Development and Validation of Chemical Features-Based Proton-Coupled Folate Transporter/Activity and Reduced Folate Carrier/Activity Models (Pharmacophores)

All clinically used antifolates lack transport selectivity for tumors over normal cells resulting in dose-limiting toxicities. There is growing interest in developing novel tumor-targeted cytotoxic antifolates with selective transport into tumors over normal cells via the proton-coupled folate trans...

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Detalhes bibliográficos
Publicado no:J Mol Graph Model
Main Authors: Shah, Khushbu, Raghavan, Sudhir, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959037/
https://ncbi.nlm.nih.gov/pubmed/29550744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2018.02.007
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