Yüklüyor......

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry

A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines, with bridge length variations (from 2-8 carbon atoms) were synthesized as selective folate receptor (FR) α and β substrates and as antitumor agents. The syntheses were accomplished from appropriate allylalcohols and 4-iodobenzoa...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Deng, Yijun, Zhou, Xilin, Desmoulin, Sita Kugel, Wu, Jianmei, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730022/
https://ncbi.nlm.nih.gov/pubmed/19371039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8011323
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!