تحميل...

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry

A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines, with bridge length variations (from 2-8 carbon atoms) were synthesized as selective folate receptor (FR) α and β substrates and as antitumor agents. The syntheses were accomplished from appropriate allylalcohols and 4-iodobenzoa...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Deng, Yijun, Zhou, Xilin, Desmoulin, Sita Kugel, Wu, Jianmei, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
التنسيق: Artigo
اللغة:Inglês
منشور في: 2009
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730022/
https://ncbi.nlm.nih.gov/pubmed/19371039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8011323
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