Oligomeric Structure of the Human Reduced Folate Carrier: IDENTIFICATION OF HOMO-OLIGOMERS AND DOMINANT-NEGATIVE EFFECTS ON CARRIER EXPRESSION AND FUNCTION

Por Hou, Zhanjun, Matherly, Larry H.
Publicado em 2009

Structure and Function of the Reduced Folate Carrier: A Paradigm of A Major Facilitator Superfamily Mammalian Nutrient Transporter

Por Matherly, Larry H., Hou, Zhanjun
Publicado em 2008

Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1

Por Hou, Zhanjun, Matherly, Larry H.
Publicado em 2014

Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency

Por Hou, Zhanjun, Orr, Steve, Matherly, Larry H.
Publicado em 2014

The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

Por Matherly, Larry H., Hou, Zhanjun, Gangjee, Aleem
Publicado no Cancer Chemother Pharmacol (2017)

The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

Por Matherly, Larry H., Wilson, Mike R., Hou, Zhanjun
Publicado em 2014

Substituted Cysteine Accessibility Reveals a Novel Transmembrane 2–3 Reentrant Loop and Functional Role for Transmembrane Domain 2 in the Human Proton-coupled Folate Transporter

Por Wilson, Mike R., Hou, Zhanjun, Matherly, Larry H.
Publicado em 2014

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

Por Desmoulin, Sita Kugel, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Publicado em 2012

Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier

Por Hou, Zhanjun, Cherian, Christina, Drews, Joseph, Wu, Jianmei, Matherly, Larry H.
Publicado em 2010

Substrate-specific binding and conformational changes involving Ser(313) and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis...

Por Hou, Zhanjun, Wu, Jianmei, Ye, Jun, Cherian, Christina, Matherly, Larry H.
Publicado em 2010

Development and Validation of Chemical Features-Based Proton-Coupled Folate Transporter/Activity and Reduced Folate Carrier/Activity Models (Pharmacophores)

Por Shah, Khushbu, Raghavan, Sudhir, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado no J Mol Graph Model (2018)

Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6–7 linker

Por Wilson, Mike R., Hou, Zhanjun, Wilson, Lucas J., Ye, Jun, Matherly, Larry H.
Publicado no Biochem J (2016)

Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-directed Mutagenesis and Affinity Inhibition

Por Deng, Yijun, Hou, Zhanjun, Wang, Lei, Cherian, Christina, Wu, Jianmei, Gangjee, Aleem, Matherly, Larry H.
Publicado em 2008

Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

Por Deis, Siobhan M., Doshi, Arpit, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem, Dann, Charles E.
Publicado no Biochemistry (2016)

Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors With Antitumor Activity

Por Deng, Yijun, Wang, Yiqiang, Cherian, Christina, Hou, Zhanjun, Buck, Steven A., Matherly, Larry H., Gangjee, Aleem
Publicado em 2008

Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake...

Por Wang, Lei, Cherian, Christina, Desmoulin, Sita Kugel, Mitchell-Ryan, Shermaine, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado em 2012

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate...

Por Deng, Yijun, Zhou, Xilin, Desmoulin, Sita Kugel, Wu, Jianmei, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado em 2009

Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de novo Purine N...

Por Wang, Yiqiang, Cherian, Christina, Orr, Steven, Mitchell-Ryan, Shermaine, Hou, Zhanjun, Raghavan, Sudhir, Matherly, Larry H., Gangjee, Aleem
Publicado em 2013

Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase...

Por Wang, Yiqiang, Mitchell-Ryan, Shermaine, Raghavan, Sudhir, George, Christina, Orr, Steven, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado no J Med Chem (2015)

Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and...

Por Wilson, Mike R., Kugel, Sita, Huang, Jenny, Wilson, Lucas J., Wloszczynski, Patrick A., Ye, Jun, Matherly, Larry H., Hou, Zhanjun
Publicado no Biochem J (2015)