Novel 5-Substituted Pyrrolo[2,3-d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents

A new series of 5-substituted thiopheneyl pyrrolo[2,3-d]pyrimidines 6–11 with varying chain lengths (n = 1–6) were designed and synthesized as hybrids of the clinically used anticancer drug pemetrexed (PMX) and our 6-substituted thiopheneyl pyrrolo[2,3-d]pyrimidines 2c and 2d with folate receptor (F...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Wang, Yiqiang, Mitchell-Ryan, Shermaine, Raghavan, Sudhir, George, Christina, Orr, Steven, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714715/
https://ncbi.nlm.nih.gov/pubmed/25602637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501787c
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