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Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de novo Purine Nucleotide Biosynthesis

A new series of 6-substituted straight side chain pyrrolo[2,3-d]pyrimidines 3a–d with varying chain lengths (n = 5–8) was designed and synthesized as part of our program to provide targeted antitumor agents with folate receptor (FR) cellular uptake specificity and glycinamide ribonucleotide formyltr...

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Detalhes bibliográficos
Main Authors: Wang, Yiqiang, Cherian, Christina, Orr, Steven, Mitchell-Ryan, Shermaine, Hou, Zhanjun, Raghavan, Sudhir, Matherly, Larry H., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880613/
https://ncbi.nlm.nih.gov/pubmed/24111942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401139z
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